Why is the DNA denaturation transition first order?

نویسندگان

  • Y Kafri
  • D Mukamel
  • L Peliti
چکیده

We study a model for the denaturation transition of DNA in which the molecules are considered as being composed of a sequence of alternating bound segments and denaturated loops. We take into account the excluded-volume interactions between denaturated loops and the rest of the chain by exploiting recent results on scaling properties of polymer networks of arbitrary topology. The phase transition is found to be first order in d = 2 dimensions and above, in agreement with experiments and at variance with previous theoretical results, in which only excluded-volume interactions within denaturated loops were taken into account. Our results agree with recent numerical simulations.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comment on "Why is the DNA denaturation transition first order?".

1 Comment on " Why is the DNA denaturation transition first order? " Recently, Kafri, Mukamel and Peliti (KMP) [1] extended the classical Poland-Scheraga (PS) model for the denaturation transition of DNA [2]. According to PS, the energetic binding of bases in the double helix competes with the entropic contribution of denatured loops, implying that the nature of the transition depends on the ex...

متن کامل

Melting and unzipping of DNA

Experimental studies of the thermal denaturation of DNA yield a strong indication that the transition is first order. This transition has been theoretically studied since the early sixties, mostly within an approach in which the microscopic configurations of a DNA molecule are given by an alternating sequence of non-interacting bound segments and denaturated loops. Studies of these models negle...

متن کامل

Protein-mediated loops and phase transition in nonthermal denaturation of DNA

We use a statistical mechanical model to study nonthermal denaturation of DNA in the presence of protein-mediated loops. We find that looping proteins which randomly link DNA bases located at a distance along the chain could cause a first-order phase transition. We estimate the denaturation transition time near the phase transition, which can be compared with experimental data. The model descri...

متن کامل

Poland-Scheraga models and the DNA denaturation transition

Poland-Scheraga models were introduced to describe the DNA denaturation transition. We give a rigorous and refined discussion of a family of these models. We derive possible scaling functions in the neighborhood of the phase transition point and review common examples. We introduce a self-avoiding Poland-Scheraga model displaying a first order phase transition in two and three dimensions. We al...

متن کامل

Renormalisation group determination of the order of the DNA denaturation transition

We report on the nature of the thermal denaturation transition of homogeneous DNA as determined from a renormalisation group analysis of the Peyrard-Bishop-Dauxois model. Our approach is based on an analogy with the phenomenon of critical wetting that goes further than previous qualitative comparisons, and shows that the transition is continuous for the average base-pair separation. However, si...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Physical review letters

دوره 85 23  شماره 

صفحات  -

تاریخ انتشار 2000